I've been running Google Chrome on both XP and Vista PCs since it became available. I discovered an annoying shortcoming about it a few minutes ago. I started downloading the Linpus Linux Lite Live CD ISO using Chrome. Since the estimated download time is around 15 hours, I decided to pause it and exit Chrome. Firefox allows you to resume a download between sessions. Unfortunately, Chrome does not. Fortunately, I tested this before powering down my Vista PC. So, I fired up Firefox 3, started the download, and paused it. I also tested closing the browser, restarting the browser, and resuming the download. This all worked fine.
The lesson learned here is to start any large file download using Firefox. It lets you pause and resume between separate sessions. Google Chrome does NOT.